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Combination of apoenzyme and coenzyme produces
a) Prosthetic group
b) Holoenzymes
c) Enzyme substrate complex
d) Enzyme- product complex

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Answer
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Hint:Enzymes are biological molecules that help in speeding up the rate of chemical reactions which take place inside the cell.

Complete answer:
Let us first understand what the terms apoenzyme and coenzyme mean. So, apoenzyme is basically an inactivated form of enzyme which is activated on binding of an organic or an inorganic factor. The factor is also known as coenzyme.

>Option a: The cofactors which bind tightly to proteins or the enzymes are known as prosthetic group. Therefore, this is the incorrect option.
>Option b: When an apoenzyme combines with coenzyme the enzyme formed is known as holoenzyme. They are the active forms of the enzyme and their major function is to convert a substrate into a product. Examples of holoenzymes are - RNA polymerase, DNA polymerase, etc. therefore, this is the correct option.
>Option c: An enzyme substrate complex can be defined as the temporary molecule formed when the enzyme combines with a substrate. Therefore, this is the incorrect option.
>Option d: Enzyme substrate complex gets converted into enzyme product complex. Therefore, this is the incorrect option.

Thus, the correct option is (b) Holoenzyme.

Note:Enzymes are used widely in the industry of - food and beverage, chemical production, biotechnology, etc.