Question

Haldane effect plays a more important role in promoting carbon dioxide transport than that of the Bohr’s effect in promoting oxygen transport because
A. Oxyhaemoglobin is a stronger acid which donates hydrogen ion (H+) which in turn displace carbon dioxide from blood
B. Carbaminohaemglobin is stronger acid which splits into hydrogen ion (H+) and bicarbonate$\left( {HC{O_3}} \right)$
C. Carbon dioxide reacts with water to form carbonic acid that lowers the pH in tissue
D. Carbon dioxide is less soluble in venous blood than in arterial blood.

Answer 1

Hint: Oxygenated blood carries large amount of $\left( {{o_2}} \right)$in it while the deoxygenated blood carries large amount of $\left( {c{o_2}} \right)$. Effect of oxygen on carbon dioxide transport known as Haldane effect. Carbon dioxide and H+ affect the affinity of hemoglobin for oxygen as described by Bohr effect.. Dissociation of carbon dioxide from hemoglobin in the presence of oxygen is promoted by Haldane effect.

Complete step by step answer: Hemoglobin is the pigment in the blood which is responsible for the red color of the blood. It also binds to the oxygen and carbon dioxide to form oxyhaemoglobin and carbaminohemoglobin. After the process of breathing diffusion of oxygen and carbon dioxide occurs. In this process chloride shift is also observed when $HCO_3^ - $ ions releases from the cell chloride ions enter into the cell to maintain electrolyte balance.
The shift in the oxygen dissociation curve caused by changes in the concentration of carbon dioxide or pH of the environment causes Bohr effect.
Partial pressure of oxygen and carbon dioxide affects the diffusion of gases with hemoglobin.
Process of oxygenation affects the amount of $C{O_2}$ transported in the blood. When the partial pressure of oxygen is lower and also the hemoglobin saturation with ${O_2}$, the more the $C{O_2}$ concentration is carried in the blood. This phenomenon is known as the Haldane effect. The ability of hemoglobin to form carbaminohemoglobin shows greater ability and to form buffer H+ by combining with it. Amount of oxygen facilitates the release of carbon dioxide. When hemoglobin becomes saturated with${O_2}$, the hydrogen ions released combine with ${O_2}$ , helping to unload from pulmonary blood. From this we can easily conclude that the Haldane effect is more important in promoting $C{O_2}$ transport than the Bohr Effect. Oxyhaemoglobin becomes more acidic by the presence of oxygen that’s why it displaces $C{O_2}$ from the blood.
From the above discussion we have reached to the conclusion that oxyhaemoglobin is a stronger acid which donates hydrogen ions (H+) which in turn displace carbon dioxide from blood.
So the correct answer is option D.

Note: High oxygen concentration enhances the diffusion of carbon dioxide and vice versa. Hemoglobin $HC{O_3}$efficiency to bind oxygen determined by Haldane effect. In Bohr Effect carbon dioxide and (H+) affect the affinity of hemoglobin determined by Bohr Effect. These effects are caused by binding of ligands at different spots of hemoglobin. Shape of Hb changes due to Haldane and Bohr Effect which causes uptake of ${O_2}$ in lungs and release of ${O_2}$ at the tissues.