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Inorganic cofactor is often called.

Answer
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Hint: Enzymes are the large biomolecules which catalyze the reaction without becoming the part of substrate converted into the product. Enzymes are the end expression of DNA. It speeds up the reaction and they are pH, temperature and substrate-specific, that means they require certain temperature and pH to work optimally.

Complete answer:
> Option A cofactor is non-
A proteinaceous substance which is bound to a protein, which is required during biological activity, generally cofactor are helper molecules which help in biochemical transformation.
The cofactor is inorganic or organic in nature and according to binding nature with enzymes, it is said to be coenzyme (loosely bounded) and prosthetic group (tightly bounded). An enzyme with cofactor is known as holoenzyme and without co-enzyme is called apo-enzyme.
An organic cofactor is common vitamins or made up of vitamins, vitamin act or serve as a precursor of organic cofactor example of cofactor are flavin, heme, while inorganic cofactor is metallic part such as metallic ion like Mg2+, Cu+, Mn2+ and many more. They are also known as an enzyme activator, which binds with enzyme molecules and increases their activity.

Hence, the correct answer is option (D).

Additional information:
> Option A. Coenzyme-
It is non-protein molecules which bind with enzymes to catalyze the chemical reaction, it does not work alone. it is used again and again to bind in many reactions.

> Option B. Prosthetic group-
It is the non-proteinaceus structure which is the part of conjugated or hetero-proteins that is covalently bind with apo-protein. They help in catalytic mechanism or activity and some of them have structural properties.

> Option C. Modulator-
These are the bio-regulatory metabolites that bind with the enzymes to make the change in enzyme structure and function and transform into allosteric enzymes which have other shape conformation.

Note: Enzyme name is mostly derived from its substrate or the chemical reaction catalyzed by it with the word ending in ase. Example maltase, amylase, protease, lactase and so on. If different enzymes catalyze the same reaction is known as iso-enzyme. Some of the enzyme classification such as transferase, isomerase, ligase, hydrolase, lyase and oxidoreductase.
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