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Hint: Nucleic acid is a type of macromolecule that may be present in all organisms and viruses. The information a cell needs to produce proteins is encoded in deoxyribonucleic acid (DNA). Ribonucleic acid (RNA) is a similar kind of nucleic acid that participates in protein synthesis in many molecular forms.
Complete answer:
A nucleoside and a phosphate make up nucleotides, which are organic compounds. They are monomeric units of the nucleic acid polymers deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), which are both important macromolecules in all living things on Earth. Nucleotides are acquired from the diet and are also produced by the liver from common components.
Nucleotides are made up of three component molecules: a nucleobase, a five-carbon sugar (ribose or deoxyribose), and a one to three-phosphate phosphate group. Guanine, adenine, cytosine, and thymine are the four nucleobases of DNA; uracil replaces thymine in RNA.
Nucleotides are also integrated into essential cofactors of enzymatic processes (e.g. coenzyme A, FAD, FMN, NAD, and NADP+) and contribute in cell signaling (cyclic guanosine monophosphate or cGMP and cyclic adenosine monophosphate or cAMP). Radionucleotides can be made by radiolabeling nucleotides with radionuclides in experimental biochemistry.
At the cellular level, nucleotides also play an important role in metabolism. They provide chemical energy throughout the cell in the form of the nucleoside triphosphates adenosine triphosphate (ATP), guanosine triphosphate (GTP), cytidine triphosphate (CTP), and uridine triphosphate (UTP) for the many cellular functions that require energy, such as amino acid, protein, and cell membrane synthesis, cell movement (both intracellularly and intercellularly), and cell fusion.
Note: In vitro and in vivo, nucleotides can be produced in a variety of ways. Protective groups can be employed in the laboratory to make nucleotides in vitro. A pure nucleoside is protected to form a phosphoramidite, which may subsequently be utilized to manufacture an oligonucleotide or produce analogues not present in nature. Nucleotides can be generated from scratch in the body or recycled through salvage mechanisms.
Complete answer:
A nucleoside and a phosphate make up nucleotides, which are organic compounds. They are monomeric units of the nucleic acid polymers deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), which are both important macromolecules in all living things on Earth. Nucleotides are acquired from the diet and are also produced by the liver from common components.
Nucleotides are made up of three component molecules: a nucleobase, a five-carbon sugar (ribose or deoxyribose), and a one to three-phosphate phosphate group. Guanine, adenine, cytosine, and thymine are the four nucleobases of DNA; uracil replaces thymine in RNA.
Nucleotides are also integrated into essential cofactors of enzymatic processes (e.g. coenzyme A, FAD, FMN, NAD, and NADP+) and contribute in cell signaling (cyclic guanosine monophosphate or cGMP and cyclic adenosine monophosphate or cAMP). Radionucleotides can be made by radiolabeling nucleotides with radionuclides in experimental biochemistry.
At the cellular level, nucleotides also play an important role in metabolism. They provide chemical energy throughout the cell in the form of the nucleoside triphosphates adenosine triphosphate (ATP), guanosine triphosphate (GTP), cytidine triphosphate (CTP), and uridine triphosphate (UTP) for the many cellular functions that require energy, such as amino acid, protein, and cell membrane synthesis, cell movement (both intracellularly and intercellularly), and cell fusion.
Note: In vitro and in vivo, nucleotides can be produced in a variety of ways. Protective groups can be employed in the laboratory to make nucleotides in vitro. A pure nucleoside is protected to form a phosphoramidite, which may subsequently be utilized to manufacture an oligonucleotide or produce analogues not present in nature. Nucleotides can be generated from scratch in the body or recycled through salvage mechanisms.
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