Question

Write equations of the following reactions:
A.Friedel-Crafts reaction alkylation of anisole.
B.Nitration of anisole.
C.Bromination of anisole.
D.Friedel-Crafts acetylation of anisole.

Answer 1

Hint:
To solve this problem, you need to know about the structure of anisole. The molecular formula of anisole is ${{\text{C}}_{\text{7}}}{{\text{H}}_{\text{8}}}{\text{O}}$. If you know the different important reactions like Friedel-Crafts alkylation and acetylation, you can solve this problem.

Complete step by step answer:
(i) We know that Friedel-Crafts alkylation reaction is the alkylation of aromatic ring using lewis acid as a catalyst with an alkyl halide. Let us write the Friedel-Crafts reaction alkylation of anisole.

(ii) We know the nitration process will be carried out by using the nitrating mixture. That is concentrated sulphuric acid and concentrated nitric acid.

(iii) Bromination of anisole is carried out with $B{r_2}$ in ethanoic acid.

(iv) We know that the Friedel-Crafts acetylation is the reaction in which the addition of an acyl group to an aromatic ring. Most of the cases, Friedel-Crafts acylation is carried out using an acid chloride.

Additional Information: In the Friedel-Crafts reaction, the carbocations formed by vinyl and aryl halides cannot be used in the reaction because it is extremely unstable. This is a limitation of Friedel-Crafts alkylation reaction.

Note: You should note that in the bromination of anisole reaction, anisole undergoes electrophilic substitution reaction which is faster than the normal benzene ring does. Three different sites are used for occurring this substitution.