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Plasma Membrane in Cells

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Introduction to Plasma Membrane

The plasma membrane is a thin boundary that covers the outer surface of a cell and separates its internal environment from the external environment. It is found in both prokaryotic and eukaryotic cells, serving as a protective, selectively permeable barrier. This means that certain substances can move in and out, while others are restricted. By controlling the exchange of materials, the plasma membrane in cell helps maintain the balance of chemicals and ions essential for life processes.


Structure of the Plasma Membrane

The plasma membrane structure is often explained using the “fluid mosaic model,” proposed by Singer and Nicolson in 1972. According to this model:


Plasma membrane


  • Phospholipid Bilayer: The membrane mainly consists of a double layer of phospholipids. Each phospholipid has a hydrophilic (water-loving) head and two hydrophobic (water-repelling) tails. This arrangement forms a flexible but stable barrier.

  • Proteins: Membrane proteins are embedded within or attached to the phospholipid bilayer. They may act as channels, carriers, receptors, or enzymes.

  • Carbohydrates: Carbohydrate chains can attach to proteins or lipids (glycoproteins and glycolipids), contributing to cell recognition, adhesion, and communication.

  • Cholesterol (in eukaryotic cells): Cholesterol molecules, interspersed within the bilayer, help maintain the membrane’s fluidity and stability.


In total, the plasma membrane is about 5–8 nm thick and is flexible enough to change shape, yet robust enough to protect the cell contents.


Functions of the Plasma Membrane

  1. Selective Permeability: One key plasma membrane function is controlling what enters and exits the cell. Small, non-polar molecules usually pass through easily, while larger or charged molecules require specific transport mechanisms.

  2. Protection and Separation: It physically separates the cell’s interior (cytoplasm) from the external environment and offers protection against harmful substances.

  3. Communication and Signalling: Receptor proteins on the membrane receive chemical signals (e.g., hormones), allowing cells to communicate with each other.

  4. Endocytosis and Exocytosis: The plasma membrane in the cell facilitates the uptake of substances (endocytosis) and the expulsion of materials (exocytosis).

  5. Maintenance of Cell Shape: The plasma membrane is attached to the cytoskeleton, helping the cell maintain its shape and structure.

  6. Membrane Potential: It helps in establishing and maintaining the electrical potential across the cell membrane, crucial for nerve and muscle function in multicellular organisms.


Unique Facts About the Plasma Membrane

  • It is sometimes referred to as the plasmalemma, a term introduced by J. Q. Plowe in 1931.

  • Robert Hooke’s observation of cells in the late 1600s laid the groundwork for discovering membranes. Schwann (1839) noted a thin layer around animal cells, later identified as the plasma membrane. Cramer and Nageli named it as the cell membrane in 1855.

  • The plasma membrane structure is dynamic. Its components are constantly in motion, allowing the cell to adapt to changing conditions.

  • Different cells can have special modifications of their plasma membrane (e.g., microvilli in intestinal cells) to suit specific functions like absorption.


Difference Between the Plasma Membrane and Cell Membrane

The term cell membrane is often used interchangeably with plasma membrane, and in many contexts, they refer to the same structure. However, “cell membrane” can sometimes mean any membrane that surrounds the cell or its organelles, while “plasma membrane” specifically points to the outer membrane that encloses the cell’s cytoplasm. In many textbooks, both terms are used synonymously when discussing the outer boundary of the cell.


Quick Quiz

Test your understanding of the plasma membrane with the questions below.


1. Which part of the plasma membrane is hydrophobic?
A. Phosphate heads
B. Lipid tails
C. Carbohydrate chains
Answer: B. Lipid tails


2. Which of the following molecules can easily pass through a phospholipid bilayer without help?
A. Large proteins
B. Ions
C. Small non-polar molecules
Answer: C. Small non-polar molecules


3. Which process involves a cell taking in material from the external environment?
A. Exocytosis
B. Endocytosis
C. Osmosis
Answer: B. Endocytosis


Related Topics

FAQs on Plasma Membrane in Cells

1. Why is the plasma membrane described as a “fluid mosaic”?

The term “fluid mosaic” comes from the fluidity of the lipid bilayer and the mosaic-like arrangement of proteins, lipids, and carbohydrates scattered within it.

2. How does the plasma membrane help in cell communication?

Receptor proteins on the plasma membrane bind specific molecules (e.g., hormones), converting external signals into responses inside the cell. This process is essential for cell-to-cell communication and coordination.

3. Can the plasma membrane repair itself if it is punctured?

Yes, in many cases, the plasma membrane can reseal minor tears due to the fluid nature of its lipid bilayer. However, large ruptures can be fatal for the cell.

4. Is the plasma membrane the same in all organisms?

While the general structure is similar (a phospholipid bilayer with embedded proteins), the specific components (types of phospholipids, proteins, and carbohydrates) can vary among different organisms, reflecting their unique adaptations and environments.

5. Does temperature affect the plasma membrane?

Yes. High temperatures can increase membrane fluidity, and extremely low temperatures can make it rigid. Many organisms adjust the composition of their membranes to maintain proper fluidity in varying temperatures.